Eight arm maze animal experiment

Eight arm maze animal experiment Experiment Eight arm maze animal experiment

(Radial ARM MAZE) experiment is commonly used One of the models of evaluating animal learning memory capabilities, was established by Olton et al. In the mid-1970s. Its basic basis is to control eating animals to explore the premature of the labyrinth, and the animal can remember the space in the labyrinth. This method can simultaneously determine the work memory and reference memory. Eight arm maze is easy to operate, feasible, and distinguish between short-term work memories and long-term reference memories, which has been widely used for learning memory function evaluation.

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1) Animal adaptation to the experimental environment After 1 week, weighed, fasted for 24 hours. Since then, the normal food is restricted after the end of training (depending on the body weight, 2-3 g of rat rat), so that the body weight is maintained at 80% to 85% of normal eating rats.

2) The second day, the labyrinth arms and central distinction are divided into food particles (4 to 5 capsules, about 3 to 4 mm diameter). Then, 4 animals were placed in the middle of the labyrinth (open to the door of each arm). Let them eat freely, explore 10 min.

3) The third day, repeating the training of the next day. This process allows animals to familiarize with labyrinth environments without strong stress conditions.

4) From the fourth day, the animals are trained: all plain granules are placed near the outer end of the outer end of the outer side, allowing the animals to freechable. After eating or 10 min, the animal is removed.

5) On the fifth day, put food in the food cassette, repeat the previous day training, twice a day.

6) After the sixth day, randomly selected 4 arms, each arm placed a food formation; each arm door closed, put the animals in the middle of the maze; after 30S, arm The door opens, allowing the animals to freely move in the labyrinth and take food until the animals have finished the food granules of 4 arms. If you have not finished 10MIN, the experiment is terminated. Training twice daily, there is intervals of more than 1 h.

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